DESIGN AND CHARACTERIZATION OF INULIN CONJUGATE FOR IMPROVED INTRACELLULAR AND TARGETED DELIVERY OF PYRAZINOIC ACID TO MONOCYTES

Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes

The propensity of monocytes to migrate into sites of Tablet Mount mycobacterium tuberculosis (TB) infection and then become infected themselves makes them potential targets for delivery of drugs intracellularly to the tubercle bacilli reservoir.Conventional TB drugs are less effective because of poor intracellular delivery to this bacterial sanctua

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Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.

Libraries based on an isolated human immunoglobulin G1 (IgG1) constant domain 2 (CH2) have been previously diversified by random mutagenesis.However, native isolated CH2 is not very stable and the generation of many mutations could lead to an increase in immunogenicity.Recently, we demonstrated that engineering an additional disulfide bond and remo

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